SimpleLabs Men's Hormone Guide

Your Testosterone Is "Normal."
So Why Do You Feel Like Garbage?

The truth about what's actually stealing your energy, strength, and sex drive

For men ages 30-55 who've been told their T is fine
but know something's seriously wrong

The $30 Billion Lie

You've seen the ads. Low-T clinics everywhere. TRT will change your life. Get your testosterone back. Feel 25 again.

So you go get tested.

Your Result:
450 ng/dL
Reference Range: 300-900 ng/dL
✓ NORMAL

Your doctor says you're fine. The low-T clinic says you don't qualify. You're told to go home, eat better, exercise more, manage your stress.

But you still feel like absolute shit.

⚠️ Exhausted no matter how much you sleep
⚠️ Belly fat you can't lose
⚠️ Muscle melting off despite training
⚠️ Sex drive in the gutter
⚠️ Brain fog and zero motivation
⚠️ Moody, irritable, flat

Here's what nobody's telling you:

Your "normal" testosterone level is meaningless without the full picture.

The problem isn't your total testosterone. It's everything else your doctor isn't testing.

This guide will show you exactly what's actually happening, why your labs are useless, and what you need to test to get real answers.

We're not here to sell you on TRT. We're here to show you what's actually broken—so you can address it intelligently.

What "Normal" Testosterone Actually Feels Like

Spoiler: It feels like garbage. Here's what you're probably experiencing:

Energy Crashes

You're tired all the time. Not "need a coffee" tired—bone-deep exhaustion. You wake up feeling like you didn't sleep. Afternoons are brutal. You used to power through your day; now you're counting hours until you can collapse.

What it could be: Low free testosterone, high SHBG, or thyroid dysfunction
📊

The Belly Fat That Won't Budge

You're doing everything right—lifting, eating clean, sleeping decent—and your belly keeps growing. It's not just "dad bod." It's visceral fat accumulating around your organs, and no amount of cardio touches it.

What it could be: Insulin resistance, high estrogen, and cortisol dysfunction
💪

Muscle Loss Despite Training

You're training hard—same weights, same program—but you're getting softer. Muscle's disappearing. Strength's plateaued or dropping. Your body composition is shifting in the wrong direction even though you're putting in the work.

What it could be: Low free T, high cortisol, inadequate recovery, or poor nutrient status
🔥

Sex Drive: MIA

Libido is gone. Not just "lower than it used to be"—actually gone. You're not thinking about sex. You're not initiating. When you do have sex, it's mechanical. And you're avoiding it because performance anxiety is now a thing.

What it could be: Low free T, high estrogen, high prolactin, or SHBG binding your testosterone
🧠

Brain Fog and Zero Drive

You can't focus. Tasks that used to be automatic now require effort. You're forgetting things. Decision-making feels hard. And the drive you used to have—the ambition, the motivation to crush goals—it's just... flat.

What it could be: Low thyroid function, suboptimal T, high inflammation, or nutrient deficiencies

Sound familiar? This isn't aging. This isn't "just life." This is your body telling you something's broken—and your doctor's one-test approach isn't finding it.

Why Your Lab Results Are Useless

Let's be blunt: the standard testosterone test your doctor ordered tells you almost nothing.

1

They Only Tested TOTAL Testosterone

Here's what most doctors order: Total Testosterone. That's it.

Total testosterone is the sum of:

  • Bound testosterone (attached to SHBG and albumin—biologically inactive)
  • Free testosterone (unbound, biologically active—this is what actually matters)
The problem: You can have "normal" total T but if most of it's bound to SHBG, your free T is in the gutter—and you'll feel every symptom of low testosterone.

It's like having $10,000 in your bank account but $9,500 is frozen. On paper you're fine. In reality, you're broke.

2

"Normal Range" Is 300-900 ng/dL (Would YOU Want to Be at 300?)

The reference range for total testosterone is absurdly broad: 300-900 ng/dL.

If your result is 350 ng/dL, you're "normal." But so is someone at 850 ng/dL. Do you think those two guys feel the same?

Here's the reality: A 35-year-old man with testosterone at 350 ng/dL feels like shit. But he's "in range," so nothing gets addressed.

Many men report feeling their best at 600-900 ng/dL. Those below 500 often report struggling with energy, body composition, and drive—regardless of what the lab says is "normal."

3

They're Not Testing Estrogen (Yes, Men Need This Checked)

Most men have no idea they need to check estrogen. Most doctors don't test it unless you're on TRT.

But here's the deal: Men need estrogen. It's critical for bone density, libido, joint health, and cardiovascular function.

The problem: If your estrogen is too HIGH (from belly fat converting T to estrogen) or too LOW (from not enough T to convert), you'll have symptoms—low libido, mood swings, fat gain, gynecomastia (man boobs), joint pain.

And if your doctor isn't ordering Estradiol, Sensitive (LC/MS/MS)—the right test for men—they're flying blind.

4

They're Ignoring SHBG (The Thing Making Your T Useless)

SHBG (Sex Hormone Binding Globulin) is a protein that binds to testosterone and makes it biologically inactive.

High SHBG = Low Free Testosterone

You can have total T of 600 ng/dL (looks great!) but if your SHBG is sky-high, your free T might be 8 pg/mL (bottom of the barrel). You'll feel like your testosterone is 200 ng/dL even though your total number looks fine.

What causes high SHBG? Thyroid issues, low protein intake, insulin resistance, chronic inflammation, liver dysfunction, aging.

If your doctor didn't test SHBG, they have no idea if your testosterone is actually usable.

5

One Morning Test Doesn't Show the Pattern

Testosterone peaks in the morning and declines throughout the day. One 8 AM blood draw shows you that moment—not what's happening at noon, 5 PM, or over the course of weeks.

If you're stressed, didn't sleep well, or had a brutal training session the day before, your results could be artificially low. Or if you happened to have a great night's sleep and low stress that week, your results could look better than your baseline.

One test is a snapshot. Symptoms are a pattern.

If you're symptomatic and your one test came back "normal," you need more data—not dismissal.

What's Actually Happening (The Real Culprits)

Your "normal" testosterone isn't the problem. These are:

1

High SHBG Is Binding Your Testosterone

SHBG acts like a sponge, soaking up your testosterone and making it unavailable to your cells.

What causes high SHBG:

  • Low protein intake
  • Thyroid dysfunction (hypothyroidism)
  • Insulin resistance
  • Chronic inflammation
  • Liver issues
  • Aging
Common approaches: Optimize thyroid function, increase protein, improve insulin sensitivity, consider boron supplementation (research suggests it may lower SHBG), and address inflammation.
2

Your Estrogen Is Too High

Belly fat is metabolically active. It contains an enzyme called aromatase, which converts testosterone into estrogen.

The more belly fat you have, the more aromatase you have. The more aromatase you have, the more testosterone gets converted to estrogen. The higher your estrogen, the more belly fat you store.

This is a doom loop:
Belly fat → More aromatase → Higher estrogen → More belly fat → Even more aromatase

High estrogen symptoms in men:

  • Low libido
  • Erectile dysfunction
  • Gynecomastia (breast tissue growth)
  • Fat gain (especially around belly and chest)
  • Water retention
  • Mood swings and irritability
Common approaches: Lose belly fat (insulin sensitivity + strength training), optimize Vitamin D (natural aromatase inhibitor), increase cruciferous vegetables (DIM helps estrogen metabolism), reduce alcohol.
3

Your Cortisol Is Wrecking Everything

Cortisol is your stress hormone. Acute stress = cortisol spike (good, adaptive). Chronic stress = cortisol stays elevated (bad, catabolic).

Chronically high cortisol:

  • Suppresses testosterone production
  • Breaks down muscle tissue
  • Increases belly fat storage
  • Worsens insulin resistance
  • Tanks thyroid function
  • Disrupts sleep (which further lowers T)
Common sources of chronic cortisol elevation:
Poor sleep • Overtraining (especially chronic cardio) • Work stress • Relationship stress • Calorie restriction while training hard • Inadequate recovery

You can't out-supplement chronic stress. Address the stressor or manage your response to it.

4

Your Thyroid Is Sluggish

Thyroid hormones control your metabolic rate. When thyroid function is low, everything slows down—including testosterone production.

Low thyroid symptoms that look like low T:

  • Chronic fatigue
  • Weight gain (especially belly fat)
  • Low libido
  • Brain fog
  • Cold intolerance
  • Dry skin
  • Constipation
Here's the kicker: Most doctors only test TSH. If your TSH is "normal" (0.5-4.5) but your Free T3 is low or your Reverse T3 is high, your thyroid isn't working well—but you'll be told "your thyroid is fine."

You need comprehensive thyroid testing: TSH, Free T3, Free T4, Reverse T3, and thyroid antibodies (TPO, TgAb) to check for Hashimoto's.

5

Insulin Resistance Is the Foundation of It All

Insulin resistance is when your cells stop responding properly to insulin, so your pancreas pumps out more and more to compensate. Chronically high insulin wreaks havoc on your hormones.

How insulin resistance tanks your testosterone:

  • Increases belly fat (which increases aromatase and estrogen)
  • Suppresses SHBG production (paradoxically leading to higher SHBG later as compensation)
  • Increases inflammation
  • Disrupts LH signaling (LH tells your testes to make testosterone)
  • Impairs mitochondrial function (less energy production)
You can have insulin resistance and NOT be diabetic. You can have normal fasting glucose and still be insulin resistant. The only way to know is to test fasting insulin and HbA1c.

Improve insulin sensitivity first. Everything else gets easier after that.

6

You're Not Sleeping (So Your T Isn't Recovering)

Testosterone is produced primarily during deep sleep. Specifically, during REM and slow-wave sleep cycles.

Poor sleep = poor T recovery.

Studies show: Men who sleep 5 hours per night have 10-15% lower testosterone than men who sleep 8 hours. That's the equivalent of aging 10-15 years.

What's killing your sleep:

  • High cortisol at night (from chronic stress)
  • Alcohol (suppresses REM sleep)
  • Blue light exposure before bed
  • Poor sleep hygiene
  • Sleep apnea (especially if you're overweight)

You can't supplement your way out of sleep deprivation. 7-9 hours is non-negotiable.

7

Nutrient Deficiencies Are Sabotaging Production

Your body needs raw materials to make testosterone. If you're deficient, production suffers.

Critical nutrients for T production:

  • Vitamin D (50-70 ng/mL optimal): Acts like a steroid hormone; low D = low T
  • Zinc (15-30mg/day): Necessary for T synthesis; deficiency common in athletes
  • Magnesium (400-600mg/day): Increases free T by lowering SHBG
  • Boron (6-10mg/day): Lowers SHBG, increases free T
  • Vitamin K2: Supports testosterone production in the testes
  • Omega-3s (2000mg EPA/DHA): Reduces inflammation

If you're chronically stressed, training hard, or not eating a nutrient-dense diet, you're likely deficient in several of these.

The Tests Your Doctor Isn't Ordering

If you want the full picture, here's what you actually need to test:

A note on comprehensive testing: Most doctors will order some of these tests if you push hard enough. But getting all of them? Good luck. If your doctor won't order comprehensive testing, SimpleLabs coordinates access to complete panels through licensed practitioners—including our Complete Hormone Panel (70+ biomarkers, everything listed below) and Men's Health Panel (30+ biomarkers including PSA screening).

Complete Testosterone Panel

  • Total Testosterone (LC/MS/MS) — The gold standard method, more accurate than immunoassay
  • Free Testosterone (Calculated) — This is what actually matters
  • Bioavailable Testosterone (Calculated) — Free T + weakly-bound T
  • SHBG — The protein binding your testosterone

Estrogen & Other Hormones

  • Estradiol, Sensitive (LC/MS/MS) — Standard estradiol tests aren't accurate for men
  • DHEA-S — Adrenal androgen precursor
  • LH (Luteinizing Hormone) — Tells your testes to make testosterone
  • FSH (Follicle-Stimulating Hormone) — Related to sperm production
  • Prolactin — High prolactin kills libido and can lower T
  • IGF-1 — Growth hormone marker; important for muscle and recovery

Complete Thyroid Panel

  • TSH — Not enough on its own
  • Free T3 — Active thyroid hormone
  • Free T4 — Precursor to T3
  • Reverse T3 — Can block T3 receptors
  • Thyroid Antibodies (TPO, TgAb) — Check for Hashimoto's autoimmune thyroid disease

Metabolic Markers

  • Fasting Insulin — The ONLY way to detect insulin resistance early
  • HbA1c — 3-month average blood sugar
  • Fasting Glucose
  • Lipid Panel (Total Chol, LDL, HDL, Triglycerides)

Inflammation & Nutrients

  • hsCRP (High-Sensitivity C-Reactive Protein) — Inflammation marker
  • Vitamin D (25-OH) — Often men aim for 50-70 ng/mL
  • Vitamin B12
  • Magnesium, RBC — More accurate than serum magnesium
  • Ferritin — Iron storage; low ferritin = low energy
  • Iron Panel (Serum Iron, TIBC, Transferrin Saturation)

Additional (Baseline Health)

  • Complete Blood Count (CBC) — Red/white blood cells, hemoglobin, platelets
  • Comprehensive Metabolic Panel (CMP) — Kidney, liver, electrolytes

If Your Doctor Won't Order These Tests:

SimpleLabs' Complete Hormone Panel includes every single marker listed above—and then some. 70+ biomarkers including comprehensive hormone analysis (total/free/bioavailable testosterone via LC/MS, sensitive estradiol, SHBG, LH, FSH, prolactin, IGF-1, DHEA-S), complete thyroid panel with antibodies and Reverse T3, metabolic markers (fasting insulin, HbA1c, advanced lipid panel), inflammation (hsCRP), essential nutrients (Vitamin D, B12, Folate, RBC Magnesium, Iron panel), CBC, and CMP. All coordinated through licensed practitioners with educational support from Certified Health & Wellness Coaches.

Want to start simpler? The Hormone Snapshot Panel ($149, 5 biomarkers) gives you the hormone essentials: Total/Free/Bioavailable Testosterone, Estradiol, Cortisol, and DHEA-S—perfect for a baseline check.

Over 40 and want prostate screening? The Men's Health Panel ($399, 30+ biomarkers) includes everything hormone-related plus PSA (prostate-specific antigen) screening.

Important: All SimpleLabs testing is processed through CLIA-certified laboratories (Quest Diagnostics)—the same labs your doctor uses. This means your results are fully valid medical lab work that you can bring directly to your doctor, share with any healthcare provider, or use as part of your medical records.

What You Can Actually Do About This

You don't need TRT to address most of this. Here's what works:

Foundation 1

Improve Insulin Sensitivity First

This is the foundation. Everything gets easier after you improve this.

How:
  • Strength train 3-4x/week — Muscle is the primary site of glucose disposal
  • Eat 1g protein per pound of bodyweight — Protein improves insulin sensitivity
  • Cut refined carbs and sugar — Obvious but necessary
  • Prioritize whole foods — Vegetables, meat, fish, eggs, nuts, fruit
  • Don't eat late at night — Insulin sensitivity is lowest in the evening
Why it matters: Better insulin sensitivity = less belly fat = lower aromatase = less estrogen = higher free testosterone. Plus better energy, better body composition, lower inflammation.
Foundation 2

Manage Cortisol (Stop Overtraining)

High cortisol is testosterone's enemy. You can't out-supplement chronic stress.

How:
  • Sleep 7-9 hours — Non-negotiable
  • Cut back on chronic cardio — Long, steady-state cardio elevates cortisol
  • Take rest days seriously — Overtraining tanks T
  • Practice stress management — Breathwork, meditation, sauna, nature walks
  • Limit alcohol — Alcohol disrupts sleep, raises cortisol, lowers T
Why it matters: Lower cortisol = better testosterone production + better recovery + less belly fat + better sleep quality.
Foundation 3

Optimize Thyroid Function

Low thyroid mimics low T. Address it and everything improves.

How:
  • Get comprehensive thyroid testing — TSH, Free T3, Free T4, Reverse T3, antibodies
  • Consider selenium supplementation (commonly 200mcg/day) — Supports T4→T3 conversion
  • Ensure adequate iodine intake — Seaweed, iodized salt, fish
  • Check for Hashimoto's — If antibodies are positive, address autoimmune triggers
  • Avoid excessive soy — Can interfere with thyroid function
Why it matters: Optimal thyroid = better metabolic rate = more energy = better T production.
Foundation 4

Lower SHBG Naturally

Free up the testosterone you already have.

How:
  • Consider boron supplementation (commonly 6-10mg/day) — Research suggests it may lower SHBG and increase free T
  • Increase protein intake — Higher protein = lower SHBG
  • Optimize Vitamin D (aim for 50-70 ng/mL) — Low D increases SHBG
  • Improve insulin sensitivity — See Foundation 1
  • Strength train regularly — Resistance training lowers SHBG
Why it matters: Lower SHBG = more free testosterone = better energy, libido, muscle mass, and mood without changing total T.
Foundation 5

Dial In Your Nutrients

You can't make testosterone without raw materials.

Key supplements for T production:
  • Vitamin D3 (5000 IU/day or more; get tested, aim for 50-70 ng/mL)
  • Zinc (15-30mg/day; critical for T synthesis)
  • Magnesium (400-600mg/day; lowers SHBG, improves sleep)
  • Boron (6-10mg/day; increases free T, lowers SHBG)
  • Vitamin K2 (MK-7, 200mcg/day; supports T production)
  • Omega-3s (2000mg EPA/DHA daily; reduces inflammation)
Why it matters: If you're deficient, your body can't produce testosterone optimally—no matter what else you do.
Foundation 6

Reduce Estrogen Naturally

High estrogen tanks T, kills libido, and promotes fat gain.

How:
  • Lose belly fat — Less fat = less aromatase = less estrogen
  • Increase cruciferous vegetables — Broccoli, cauliflower, kale (contain DIM, supports estrogen metabolism)
  • Optimize Vitamin D — Natural aromatase inhibitor
  • Limit alcohol — Alcohol increases aromatase activity
  • Avoid xenoestrogens — Plastics (BPA), pesticides, synthetic fragrances
  • Consider DIM supplementation (commonly 200-400mg/day) — May help metabolize estrogen
Why it matters: Lower estrogen = better T:E ratio = improved libido, body composition, mood, and performance.

When TRT Actually Makes Sense

Let's be clear: TRT is not a first-line solution. It's a tool—and like any tool, it's appropriate in specific situations and inappropriate in others.

TRT might be appropriate if:

  • Your total testosterone is consistently below 300 ng/dL (tested multiple times, early morning)
  • Your free testosterone is very low (<8 pg/mL) despite lifestyle optimization
  • You've been diagnosed with hypogonadism by a qualified healthcare provider (based on comprehensive hormone testing and clinical evaluation)
  • You've already addressed the foundations: insulin sensitivity, cortisol management, thyroid function, sleep, nutrient status
  • Your symptoms are significantly impacting quality of life and haven't improved with lifestyle changes

TRT is NOT appropriate if:

  • Your total T is 400+ ng/dL but you haven't checked free T, SHBG, estrogen, thyroid, or insulin
  • You're insulin resistant, cortisol-dysregulated, or thyroid-dysfunctional and haven't addressed it
  • You're overweight with high body fat (you'll just aromatize T into estrogen and feel worse)
  • You're not sleeping, overtraining, or chronically stressed
  • You haven't tried optimizing lifestyle factors for at least 3-6 months
  • A low-T clinic is pushing you into it without comprehensive testing

Here's the honest truth: Most men with "low T" symptoms don't actually have low testosterone. They have high SHBG, high estrogen, low thyroid, insulin resistance, or chronic stress—and TRT won't fix those root causes.

The TRT Trap

Low-T clinics are incentivized to put you on TRT regardless of your actual levels. Once you start, you're a customer for life. They won't check your estrogen, SHBG, or thyroid. They won't address insulin resistance. They'll just give you testosterone—and if you feel worse (because your estrogen skyrockets), they'll sell you an estrogen blocker.

Get the full picture first.

If you're considering TRT, get comprehensive testing first. SimpleLabs' Complete Hormone Panel gives you everything you need to make an informed decision: total/free/bioavailable T, estradiol, SHBG, LH, FSH, prolactin, complete thyroid, insulin, and more. Make the decision with data—not marketing.

You're Not "Getting Old"

Society tells men to accept decline. "Dad bod" is normalized. Low energy in your 40s is expected. Losing muscle, gaining belly fat, having no sex drive—that's just "aging."

Bullshit.

You're not "just getting old." You're inflamed. You're insulin resistant. You're sleep-deprived. You're nutrient-deficient. Your cortisol is jacked. Your thyroid is sluggish. Your SHBG is too high. Your estrogen is out of balance.

Your body is responding logically to the stress it's under.

The fatigue, the belly fat, the brain fog, the vanished sex drive—these aren't inevitable. They're signals from a system under strain.

And the good news? Most of this is fixable without TRT.

Improve insulin sensitivity. Manage cortisol. Optimize thyroid. Lower SHBG. Get the right nutrients. Sleep 8 hours. Stop chronic cardio. Lift heavy things.

Your "normal" testosterone level isn't the problem. The problem is that nobody's testing what actually matters.

SimpleLabs is here to help you get the data you need. We coordinate access to comprehensive lab testing (through licensed practitioners and CLIA-certified labs) with educational support from Certified Health & Wellness Coaches. We're not doctors, and we're not trying to replace your medical care—we're here to help you get complete data so you can make informed decisions and advocate for yourself effectively.

You're not broken.

You're not "just getting old."

You're just done accepting "normal" when you know something's off.

Let's fix it.

What's Next?

Ready to get answers? Here's what you can do:

2

Men Over 40: Add Prostate Screening

The Men's Health Panel includes everything hormone-related plus PSA (prostate-specific antigen) screening. 30+ biomarkers including testosterone, estradiol, SHBG, DHEA-S, plus metabolic and cardiovascular markers.

View Men's Health Panel ($399)
3

Learn More About Testosterone Optimization

Access educational resources on hormone optimization, what optimal lab ranges actually mean, and how to interpret your results in context.

Explore Education Hub
4

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